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PUBLICATIONS

28. Yang A, Liu S, Zhang Y, Chen J, Fan Y, Wang F, Zou Y, Feng S, Wu J, Hu Q. Regulation of RAS Palmitoyltransferases by accessory proteins and palmitoylation. Nature Structural and Molecular Biology.  2023 doi: 10.1038/s41594-023-01183-5

27. Wang F, Naowarojna N, Zou Y. Stratifying Ferroptosis Sensitivity in Cells and Tissues with PALP. Methods in Molecular Biology. 2023;2712:9-17. doi: 10.1007/978-1-0716-3433-2_2.

26. Han JR, Yang Y, Wu TW, Shi TT, Li W, Zou Y. A Minimally-Invasive Method for Serial Cerebrospinal Fluid Collection and Injection in Rodents with High Survival Rates. Biomedicines 2023 doi: 10.3390/

biomedicines11061609.

25. Naowarojna N*, Wu T. W*, Pan Z, Li M, Han J. R,  Zou Y. Dynamic Regulation of Ferroptosis by Lipid Metabolism. Antioxidants & redox signaling 2023 doi: 10.1089/ars.2023.0278

Fig.4_wix.tif

24. Wang F, Naowarojna N, Zou Y. Stratifying ferroptosis sensitivity in cells and mouse tissues by photochemical activation of lipid peroxidation and fluorescent imaging. STAR Protocols 2022 doi: 10.1016/j.xpro.2022.101189

23. Wang F*, Graham ET*, Naowarojna N*, Shi Z*, Wang Y, Xie G, Zhou L, Salmon W, Jia J, Wang X, Huang Y, Schreiber SL#, Zou Y#. PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ. Cell Chemical Biology 2021 doi: 10.1016/j.chembiol.2021.11.001 (*co-first author, #co-corresponding author)

PALP_Graphical abstract.jpg

22. Pan Z*, Naowarojna N*, Wang Y, Hu M, Zou Y. Neutrophil ferroptotic death promotes autoimmune pathogenesis. SCIENCE CHINA Life Sciences 2021 Sept 30. (Research Highlight).  (*co-first author)

doi: 10.1007/s11427-021-2014-4

21. Shi Z*, Naowarojna N*, Pan Z, Zou Y. Multifaceted mechanisms mediating cystine starvation-induced ferroptosis. Nature Communications 2021 Aug 09. (Commentary)

 

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doi: 10.1038/s41467-021-25159-5. (*co-first author)

41467_2021_25159_Fig1_HTML.webp_as=webp.webp

20. Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020.

19. Zou Y*,#, Henry WS*, Ricq EL*, Graham ET, Maretich P, Paradkar S, Phadnis VV, Boehnke N, Deik AA, Reinhardt F, Eaton JK, Ferguson B, Wang W, Fairman J, Keys H, Dančík V, Clish CB, Clemons PA, Hammond PT, Boyer LA, Weinberg RA#, and Schreiber SL#. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature 2020 Sep 16. doi: 10.1038/s41586-020-2732-8.  (*co-first author, #co-corresponding author)

18. Zou Y* & Schreiber SL*. Progress in understanding ferroptosis and challenges in its targeting for therapeutic benefit. Cell Chemical Biology 2020 April; 27(4): 463-471. (Perspective) (*co-corresponding author).

 

https://doi.org/10.1016/j.chembiol.2020.03.015

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17. Zou Y*,#, Li H*, Graham ET, Deik AA, Eaton JK, Wang, Sandoval-Gomez G, Clish, Doench JG, & Schreiber SL#. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nature Chemical Biology 2020 Mar;16(3):302-309.  PMID: 32080622.

(*co-first author, #co-corresponding author)

 

https://doi.org/10.1038/s41589-020-0472-6

Nature chem biol clip1.jpg

16. Aragón A*, Wang Q*, Zou Y*, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Márquez JA, Hadjantonakis A-K, Macias MJ, and Massagué J. Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer directed TGF-β signaling. Genes&Development 2019 Nov 1;33(21-22):1506-1524. doi:10.1101/gad.330837.119. (*co-first author, listed in alphabetical order.)

15. Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik AA, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, Barretina J, Pagliarini RA, Galli GG, Root DE, Hahn WC, Tsherniak A, Giannakis M, Schreiber SL, Clish CB, Garraway LA, and Sellers WR. The landscape of cancer cell line metabolism. Nature Medicine 2019 May;25(5):850-860. PMID: 31068703.

14. Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng Y-Y, Deasy R, Alimova M, Dančik V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench J, Clish CB, Clemons PA, and Schreiber SL. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nature Communications 2019 Apr 8;10(1):1617. PMID: 30962421. doi: https://doi.org/10.1038/s41467-019-09277-9

13. Su J, Morgani SM, David CJ, Wang Q, Er EE, Huang Y-H, Basnet H, Zou Y, Shu W, Hendrickson RC, Soni RK, Hadjantonakis A-K, and Joan Massagué. TGF-β Orchestrates Fibrogenic and Developmental EMTs Through the RAS Effector RREB1. Nature 2020 Jan; 577(7791): 566-571. PMID: 31915377.

12. Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Griscom B, Giancotti F, Schachner M, Malladi S, and Massagué J. Pericytic Spreading of Disseminated Cancer Cells Activates YAP for Metastatic Outgrowth. Nature Cell Biology 2017 July 23. PMID: 30038252.

11. Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragon E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Marquez JA, Massagué J and Macias M. Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nature Communications 2017 Dec 12; 8(1):2070. PMID: 29234012.

10. Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E and Massagué J. Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis. Cell 2017 Mar 9;168(6):1101-1113. PMID: 28283064

9. Wang Q*, Zou Y*, Nowotschin S, Li Q, Soh C-L, Kim SY, Xi Q, Zhang C, Su J, Shu W, Huangfu D, Hadjantonakis A-K and Massagué J.  The p53 family coordinates Wnt and Nodal Inputs for mesendoderm differentiation of embryonic stem cells. Cell Stem Cell 2017 Jan 5;20(1):70-86.

 

https://doi.org/10.1016/j.stem.2016.10.002. PMID: 27889317.

(*Co-first author)

p53 CSC clip1.jpg

8. Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E and Massagué J. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 2016 Mar 24;165(1):45-60. PMID: 27015306.

7. David CJ, Huang Y-H, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA and Massagué J. TGF-β tumor suppression through a lethal EMT. Cell 2016 Feb 25;164(5):1015-30. PMID: 26898331.

6. Obenauf AC, Zou Y*, Ji AL*, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS and Massagué J. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 2015 Apr 16;520(7547):368-72. PMID: 25807485. (*Equal contribution)

5. Vanharanta S, Marney CB, Shu W, Valiente M, Zou Y, Mele A, Darnell RB and Massagué J. Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife. 2014 Jun 4;3. PMID: 24898756. 

4. Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA and Massagué J. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013 Aug 29;154(5):1060-73. PMID: 23993096. 

3. Morris LG, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan Ş, Eng S, Kannan K, Zou Y, Peng L, Banuchi VE, Paty P, Zeng Z, Vakiani E, Solit D, Singh B, Ganly I, Liau L, Cloughesy TC, Mischel PS, Mellinghoff IK and Chan TA. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nature Genetics. 2013 Mar;45(3):253-61. PMID: 23354438.

2. Chen R, Zou Y, Mao D, Sun D, Gao G, Shi J, Liu X, Zhu C, Yang M, Ye W, Hao Q, Li R and Yu L. The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation. Journal of Cell Biology. 2014 Jul 21;206(2):173-82. PMID: 25049270.

1. Zhao Q, Li S, Xue F, Zou Y, Chen C, Bartlam M and Rao Z. Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1. Journal of Virology. 2008 Sep;82(17):8647-55. PMID: 1856253

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